Category Archives: Metabolism

Bacterial Biosynthetic Gene Clusters Encoding the Anti-cancer Haterumalide Class of Molecules BIOGENESIS OF THE BROAD SPECTRUM ANTIFUNGAL AND ANTI-OOMYCETE COMPOUND, OOCYDIN A

Haterumalides are halogenated macrolides with strong anti- tumor properties, making them attractive targets for chemical synthesis. Unfortunately, current synthetic routes to these mol- ecules are inefficient. The potent haterumalide, oocydin A, was previously identified from two plant-associated bacteria through its … Continue reading

Posted in Metabolism, Natural Products | Tagged | Leave a comment

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

This review appears in Nature Reviews Neuroscience and explores the experimental evidence for a “microbiota–gut–brain axis” that may modulate brain function and behavior. Though personally I’m not convinced there’s anything more in the data presented here than associations (rather than … Continue reading

Posted in Metabolism, Microbial communication, Microbial Communities, Microbiome, Symbiosis | 1 Comment

Chemical Perturbation of Secondary Metabolism Demonstrates Important Links to Primary Metabolism

Hi everyone, Here is an article that was mentioned at the last journal club. It’s in Chemistry and Biology and this is the abstract: Bacterially produced secondary metabolites are used as antibiotics, anticancer drugs, and for many other medicinal applications. … Continue reading

Posted in Metabolism, Natural Products | Tagged | Leave a comment