Category Archives: Analysis tools

“Function-First” Lead Discovery: Mode of Action Profiling of Natural Product Libraries Using Image-Based Screening

Cytological profiling is a high-content image-based screening technology that provides insight into the mode of action (MOA) for test compounds by directly measuring hundreds of phenotypic cellular features. We have extended this recently reported technology to the mechanistic characterization of … Continue reading

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Incorporating 16S Gene Copy Number Information Improves Estimates of Microbial Diversity and Abundance

Kembel SW, Wu M, Eisen JA, Green JL (2012) Incorporating 16S Gene Copy Number Information Improves Estimates of Microbial Diversity and Abundance. PLoS Comput Biol 8(10): e1002743. doi:10.1371/journal.pcbi.1002743 The abundance of different SSU rRNA (“16S”) gene sequences in environmental samples … Continue reading

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High-Throughput Characterization and Comparison of Microbial Communities

Halwachs et al. 2012 Computational Medicine The human microbiome plays an important role in health and disease, but the structure of the bacterial communities and their interaction with the human body are still poorly understood. The recent introduction of next-generation … Continue reading

Posted in Analysis tools, Metagenomics, Microbial Communities, Microbial Ecology, Microbiome | Tagged | Leave a comment