Author Archives: JoLab

Complex archaea that bridge the gap between prokaryotes and eukaryotes

Fascinating paper in Nature this week reporting on a novel archaeal phylum, Lokiarchaeota- a missing link in evolution of eukaryotes. http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14447.html Abstract The origin of the eukaryotic cell remains one of the most contentious puzzles in modern biology. Recent studies have provided … Continue reading

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Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

Abstract Interactions between the microbiota and distal gut are fundamental determinants of human health. Such interactions are concentrated at the colonic mucosa and provide energy for the host epithelium through the production of the short-chain fatty acid butyrate. We sought … Continue reading

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Inhibition of Cell Differentiation in Bacillus subtilis by Pseudomonas protegens

A nice story based on a screen to identify soil bugs that inhibit Bacillus biofilm formation/sporulation from Elizabeth Shank’s group at UNC: Interspecies interactions have been described for numerous bacterial systems, leading to the identification of chemical compounds that impact … Continue reading

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Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity.

The last author, Sean Davies, gave a presentation at ACS that’s being picked up by some news outlets and covered the content of this June 2014 paper. In light of our discussion of obesity during this week’s journal club, I … Continue reading

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Gordon lab articles on antibodies targeted towards B. theta

Here are the links to papers from the Gordon lab on the immune response to B. theta and specific antibodies that target the capsule and LPS that we discussed during journal club. New 2015 paper in J. Bio Chem: http://www.ncbi.nlm.nih.gov/pubmed/25795776Continue reading

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Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota

Interesting paper using AI-2 to modify gut microbiota composition. http://www.cell.com/cell-reports/abstract/S2211-1247(15)00207-7 Highlights Streptomycin almost clears Firmicutes as Bacteroidetes dominate the gut microbiota Engineered Escherichia coli manipulate AI-2 levels in the mouse gut AI-2 produced by E. coli favors the Firmicutes while hindering … Continue reading

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Distinct signatures of host–microbial meta-metabolome and gut microbiome in two C57BL/6 strains under high-fat diet

A new paper out in ISME evaluates the gut metabolome in 2 different mouse lines and finds differences that they propose have to do with variations in the gut microbiota between the two types of mice.  Interesting and has some … Continue reading

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