Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota

Interesting paper using AI-2 to modify gut microbiota composition.

http://www.cell.com/cell-reports/abstract/S2211-1247(15)00207-7

Highlights

  • Streptomycin almost clears Firmicutes as Bacteroidetes dominate the gut microbiota
  • Engineered Escherichia coli manipulate AI-2 levels in the mouse gut
  • AI-2 produced by E. coli favors the Firmicutes while hindering the Bacteroidetes
  • AI-2 can shape the microbiota composition under conditions of dysbiosis
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