Monthly Archives: March 2015

Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity.

The last author, Sean Davies, gave a presentation at ACS that’s being picked up by some news outlets and covered the content of this June 2014 paper. In light of our discussion of obesity during this week’s journal club, I … Continue reading

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Gordon lab articles on antibodies targeted towards B. theta

Here are the links to papers from the Gordon lab on the immune response to B. theta and specific antibodies that target the capsule and LPS that we discussed during journal club. New 2015 paper in J. Bio Chem: http://www.ncbi.nlm.nih.gov/pubmed/25795776Continue reading

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Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota

Interesting paper using AI-2 to modify gut microbiota composition. http://www.cell.com/cell-reports/abstract/S2211-1247(15)00207-7 Highlights Streptomycin almost clears Firmicutes as Bacteroidetes dominate the gut microbiota Engineered Escherichia coli manipulate AI-2 levels in the mouse gut AI-2 produced by E. coli favors the Firmicutes while hindering … Continue reading

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Distinct signatures of host–microbial meta-metabolome and gut microbiome in two C57BL/6 strains under high-fat diet

A new paper out in ISME evaluates the gut metabolome in 2 different mouse lines and finds differences that they propose have to do with variations in the gut microbiota between the two types of mice.  Interesting and has some … Continue reading

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Proteomics as the final step in the functional metagenomics study of antimicrobial resistance

Review that might be of interest to some: The majority of clinically applied antimicrobial agents are derived from natural products generated by soil microorganisms and therefore resistance is likely to be ubiquitous in such environments. This is supported by the … Continue reading

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Kin cell lysis is a danger signal that activates antibacterial pathways of Pseudomonas aeruginosa

New eLife paper from the Mougous lab with Brook Peterson as a middle author, on how Pseudomonas cells can sense death of their neighbors and changes their fitness in co-culture. http://elifesciences.org/content/4/e05701?utm_source=content_alert&utm_medium=email&utm_content=fulltext&utm_campaign=elife-alerts

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Phage-mediated Dispersal of Biofilm and Distribution of Bacterial Virulence Genes Is Induced by Quorum Sensing

We’ll be going over the following paper in journal club this week with a discussion led by Megan: http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1004653

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