Monthly Archives: September 2014

A Drosophila Genetic Resource of Mutants to Study Mechanisms Underlying Human Genetic Diseases

Highlights • A Drosophila resource of mutants affecting adult neural development and maintenance • Essential fly genes with multiple human homologs are often associated with disease • Variants in human homologs of these genes are associated with Mendelian disease • … Continue reading

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Follow-up to “Rescuing US biomedical research from its systemic flaws” article

I saw a GoogleAlert for Jo earlier this week, and she was quoted in an article on the Science website following up on the Alberts et. al. report in PNAS on how we need to change the graduate research training … Continue reading

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‘Animated Life: Seeing the Invisible’

Quite lovely animated short on Leeuwenhoek and his discovery of the invisible world. http://www.nytimes.com/2014/09/16/opinion/animated-life-seeing-the-invisible.html?smid=tw-share

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A Deregulated Intestinal Cell Cycle Program Disrupts Tissue Homeostasis, Without Affecting Longevity in Drosophila.

Here’s a link to the paper I will discuss at journal club on Tuesday. Please bring any papers to share! http://www.jbc.org/content/early/2014/08/28/jbc.M114.578708.short

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Multifunctional Nutrient-Binding Proteins Adapt Human Symbiotic Bacteria for Glycan Competition in the Gut by Separately Promoting Enhanced Sensing and Catalysis

New in mBio from Eric Martens’ lab at Michigan; starch-binding cell surface proteins in B. theta. Abstract:  To compete for the dynamic stream of nutrients flowing into their ecosystem, colonic bacteria must respond rapidly to new resources and then catabolize … Continue reading

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Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes

Most current approaches for analyzing metagenomic data rely on comparisons to reference genomes, but the microbial diversity of many environments extends far beyond what is covered by reference databases. De novo segregation of complex metagenomic data into specific biological entities, … Continue reading

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