Monthly Archives: August 2014

Commensal-pathogen interactions in the intestinal tract: Lactobacilli promote infection with, and are promoted by, helminth parasites

Interesting new article out in Gut Microbes.  Epub ahead of print, while full text can be viewed, no PDF is available.  Shows an interesting relationship between microbiota, host response and parasite.  Raises questions about potential negative effects of what we … Continue reading

Posted in Uncategorized | Leave a comment

Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses

This is nuts!  This story was mentioned in the ASM news digest for this week–injecting spores of a species of “flesh-eating” Clostridium found in soil directly into tumors allows for the bacteria to effectively eat the tumor to get rid … Continue reading

Posted in Uncategorized | Leave a comment

Pigments as MAMPs

This is pretty cool!   AhR sensing of bacterial pigments regulates antibacterial defence The aryl hydrocarbon receptor (AhR) is a highly conserved ligand-dependent transcription factor that senses environmental toxins and endogenous ligands, thereby inducing detoxifying enzymes and modulating immune cell … Continue reading

Posted in Uncategorized | Leave a comment

Do you ORCID? Should you?

My postdoc fellowship (HFSP) encouraged all fellows to get an ORCID number some time ago. In the last year I have seen more and more entities using these numbers for research scientists (journals w/ID in byline, grant applications (NIH and … Continue reading

Posted in Uncategorized | Leave a comment

Rasgon Lab paper – Anopheles microbiota prevents wolbachia transmission

Native microbiome impedes vertical transmission ofWolbachia in Anopheles mosquitoes Significance Factors influencing Wolbachia transfer into new species remain poorly understood. This is important as Wolbachia can influence speciation and is being developed as a novel arthropod-borne disease control approach. We … Continue reading

Posted in Uncategorized | Leave a comment

Blaser paper – Missing microbes and obesity

Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting Metabolic Consequences http://www.cell.com/cell/abstract/S0092-8674(14)00821-6 Highlights •Early life is a critical window of host-microbe metabolic interaction •Low-dose penicillin treatment amplifies diet-induced obesity •A transient early microbiota perturbation leads to long-term increased … Continue reading

Posted in Uncategorized | Leave a comment

Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes

This seems pretty exciting! Abstract: The connection between an altered gut microbiota and metabolic disorders such as obesity, diabetes, and cardiovascular disease is well established1, 2. Defects in preserving the integrity of the mucosal barriers can result in systemic endotoxaemia … Continue reading

Posted in Uncategorized | Leave a comment