The Intestinal Microbiota Interferes with the microRNA Response upon Oral Listeria Infection

New paper in mBio from Pascale Cossart’s lab discusses the role of microbiota in protecting against Listeria infection.  Not in the traditional way we think of, though; this is more targeted towards how the microbiota influences host gene & protein expression, which then affects infection outcome.  The experiments examine how miRNA expression is affected in conventional vs. germfree mice, infected and not infected with Listeria.  They find a differential expression of miRNAs dependent upon the presence of microbiota.  Of interest to those of us who think about host changes in the intestinal lining & how this impacts interactions with microbes!

http://mbio.asm.org/content/4/6/e00707-13

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