Monthly Archives: July 2013

Probiotic Bacteria Reduce Salmonella Typhimurium Intestinal Colonization by Competing for Iron

New paper in Cell Host Microbe about probiotics and interactions with a pathogen, Salmonella. Abstract:  Host inflammation alters the availability of nutrients such as iron to limit microbial growth. However, Salmonella enterica serovar Typhimurium thrives in the inflamed gut by scavenging for … Continue reading

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Predicting and Manipulating Cardiac Drug Inactivation by the Human Gut Bacterium Eggerthella lenta

Abstract: Despite numerous examples of the effects of the human gastrointestinal microbiome on drug efficacy and toxicity, there is often an incomplete understanding of the underlying mechanisms. Here, we dissect the inactivation of the cardiac drug digoxin by the gut … Continue reading

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Dysbiosis of the Gut Microbiota Is Associated with HIV Disease Progression and Tryptophan Catabolism

Pretty cool Science Translational Medicine paper just out; a disrupted gut microbiota enhances progression of HIV, even when patients are already undergoing HIV therapy. Abstract: Progressive HIV infection is characterized by dysregulation of the intestinal immune barrier, translocation of immunostimulatory … Continue reading

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Alteration in Bacillus thuringiensis toxicity by curing gut flora: novel approach for mosquito resistance management

Abstract: Mosquitoes are known for acquiring resistance against insecticides in many ways, namely target side mutation, enzyme modification, sequestration, quick elimination, etc. But, the role of microflora present in abundance in the larval midgut is less explored with respect to … Continue reading

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Role of sortase-dependent pili of Bifidobacterium bifidum PRL2010 in modulating bacterium–host interactions

New PNAS paper that actually looks at probiotic-host interactions on a molecular biology level! Abstract:  Bifidobacteria represent one of the dominant groups of microorganisms colonizing the human infant intestine. Commensal bacteria that interact with a eukaryotic host are believed to … Continue reading

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Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products

ABSTRACT: Complex microbial ecosystems contain large reservoirs of unexplored biosynthetic diversity. Here we provide an experimental framework and data analysis tool to facilitate the targeted discovery of natural-product biosynthetic gene clusters from the environment. Multiplex sequencing of barcoded PCR amplicons … Continue reading

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Integrated Metabolomics Approach Facilitates Discovery of an Unpredicted Natural Product Suite from Streptomyces coelicolor M145

If I recall correctly, Erin Carlson gave a talk here recently. Abstract: Natural products exhibit a broad range of biological properties and have been a crucial source of therapeutic agents and novel scaffolds. Although bacterial secondary metabolomes are widely explored, … Continue reading

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