Monthly Archives: November 2012

Bacterial Biosynthetic Gene Clusters Encoding the Anti-cancer Haterumalide Class of Molecules BIOGENESIS OF THE BROAD SPECTRUM ANTIFUNGAL AND ANTI-OOMYCETE COMPOUND, OOCYDIN A

Haterumalides are halogenated macrolides with strong anti- tumor properties, making them attractive targets for chemical synthesis. Unfortunately, current synthetic routes to these mol- ecules are inefficient. The potent haterumalide, oocydin A, was previously identified from two plant-associated bacteria through its … Continue reading

Posted in Metabolism, Natural Products | Tagged | Leave a comment

Incorporating 16S Gene Copy Number Information Improves Estimates of Microbial Diversity and Abundance

Kembel SW, Wu M, Eisen JA, Green JL (2012) Incorporating 16S Gene Copy Number Information Improves Estimates of Microbial Diversity and Abundance. PLoS Comput Biol 8(10): e1002743. doi:10.1371/journal.pcbi.1002743 The abundance of different SSU rRNA (ā€œ16Sā€) gene sequences in environmental samples … Continue reading

Posted in Analysis tools, Metagenomics, Microbial Communities | Tagged | Leave a comment